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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 123-138 doi: 10.1007/s11705-022-2194-7
关键词: NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem
Jiao HU,Xiufan LIU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 11-24 doi: 10.15302/J-FASE-2016092
关键词: avian influenza virus H9N2 H5N1 novel viruses public health
《医学前沿(英文)》 页码 924-938 doi: 10.1007/s11684-023-1004-z
关键词: ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1
ZHANG, H. DU, D. XUE, P. GU
《机械工程前沿(英文)》 2021年 第16卷 第2期 页码 379-392 doi: 10.1007/s11465-020-0607-1
关键词: product design robust design design optimization uncertainties
Seasonal microbial community shift in a saline sewage treatment plant
Qingmei YAN, Xuxiang ZHANG, Tong ZHANG, Herbert H P FANG
《环境科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 40-47 doi: 10.1007/s11783-011-0304-8
关键词: sewage treatment plants polymerase chain reaction (PCR) denaturing gradient gel electrophoresis (DGGE) canonical correspondence analysis correspondence analysis
Hiep Thuan Lu, Wen Li, Ehsan Soroodan Miandoab, Shinji Kanehashi, Guoping Hu
《化学科学与工程前沿(英文)》 2021年 第15卷 第3期 页码 464-482 doi: 10.1007/s11705-020-1983-0
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 373-386 doi: 10.1007/s11705-022-2223-6
关键词: carbon cloth NiCo2O4 nanowires core−shell structure quinone-rich electric double layer capacitor
A pre-compensation method of the systematic contouring error for repetitive command paths
H. CHEN,Y. P. CHEN
《机械工程前沿(英文)》 2015年 第10卷 第4期 页码 367-372 doi: 10.1007/s11465-015-0367-5
For a repetitive command path, pre-compensating the contouring error by modifying the command path is practical. To obtain the pre-compensation value with better accuracy, this paper proposes the use of a back propagation neural network to extract the function of systematic contouring errors. Furthermore, by using the extracted function, the contouring error can be easily pre-compensated. The experiment results verify that the proposed compensation method can effectively reduce contouring errors.
关键词: contouring error pre-compensation motion control system back propagation (BP) neural network
Yixin Zhang, Lu Zhou, Liqing Chen, Yang Guo, Fanhui Guo, Jianjun Wu, Baiqian Dai
《化学科学与工程前沿(英文)》 2021年 第15卷 第3期 页码 518-527 doi: 10.1007/s11705-020-1926-9
Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management
Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 147-156 doi: 10.1007/s11684-010-0030-9
关键词: influenza A virus H1N1 subtype pandemic pathogenesis virulence factors immunity management antiviral
用于设计量子点元胞自动机算术电路的可扩展 1 位全加器 Research Article
Hamideh KHAJEHNASIR-JAHROMI, Pooya TORKZADEH, Massoud DOUSTI
《信息与电子工程前沿(英文)》 2022年 第23卷 第8期 页码 1264-1276 doi: 10.1631/FITEE.2100287
Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE
《化学科学与工程前沿(英文)》 2009年 第3卷 第3期 页码 305-309 doi: 10.1007/s11705-009-0021-z
PAK1 is a novel cardiac protective signaling molecule
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 399-403 doi: 10.1007/s11684-014-0380-9
We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase 1 (PAK1), a member of a serine/threonine protein kinase family. Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity is key in the regulation of a number of cellular functions, the role of PAK1 in the heart has only been revealed over the past few years. In this review, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiac protective effects. We present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellular processes in which regulation of protein phosphorylation states by protein phosphatase 2A (PP2A) predominates. We discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its role in maintaining ventricular Ca2+ homeostasis and electrophysiological stability under physiological, β-adrenergic and hypertrophic stress conditions.
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用 Article
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
《工程(英文)》 2024年 第32卷 第1期 页码 42-57 doi: 10.1016/j.eng.2023.08.001
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.
关键词: COBRA Influenza A Salmonella Vaccine Broad spectral protection
标题 作者 时间 类型 操作
Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry
Jiao HU,Xiufan LIU
期刊论文
noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis
期刊论文
Robust design approach to the minimization of functional performance variations of products and systems
ZHANG, H. DU, D. XUE, P. GU
期刊论文
Seasonal microbial community shift in a saline sewage treatment plant
Qingmei YAN, Xuxiang ZHANG, Tong ZHANG, Herbert H P FANG
期刊论文
The opportunity of membrane technology for hydrogen purification in the power to hydrogen (P2H) roadmap
Hiep Thuan Lu, Wen Li, Ehsan Soroodan Miandoab, Shinji Kanehashi, Guoping Hu
期刊论文
NiCo2O4@quinone-rich N–C core–shell nanowires as composite electrode for electric double layer capacitor
期刊论文
A pre-compensation method of the systematic contouring error for repetitive command paths
H. CHEN,Y. P. CHEN
期刊论文
Synthesis of zeolite Na-P1 from coal fly ash produced by gasification and its application as adsorbent
Yixin Zhang, Lu Zhou, Liqing Chen, Yang Guo, Fanhui Guo, Jianjun Wu, Baiqian Dai
期刊论文
Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management
Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,
期刊论文
Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE
期刊论文